A Multi-modal Collagen Nucleic Acid Delivery System for the Modulation of Inflammation and the Promotion of Angiogenesis
Shane received his bachelors’ degree in Biomedical Engineering in 2009 from NUI Galway. He pursued a PhD in Biomaterials in NUI Galway working under the supervision of Professor Abhay Pandit. During his PhD, Shane has spent time in the laboratory of Prof. Katja Schenke-Layland at the Fraunhofer institute in Stuttgart, Germany and Prof. Dulce Papy-Garcia at CRRET in University Paris Creteil.
Shane’s doctoral research has focused on the development of an injectable collagen-based delivery system for anti-inflammatory and pro-angiogenic nucleic acids. Collagen hollow spheres and an injectable hydrogel were developed and assembled in order to deliver therapeutic nucleic acids. This injectable system has been evaluated in vitro and also in a subcutaneous animal model. During his PhD, he has authored three research articles (Molecular Pharmaceutics, Tissue Engineering and Journal of Material Chemistry B), and has been a co-author in a number of other articles. There are two additional first author manuscripts in submission. In addition, he has also presented his work at several key national and international conferences. He has secured a postdoctoral fellowship at University of California, Berkley (Kevin Healy Laboratory).
Professor Kevin Shakesheff is Director of the UK Regenerative Medicine Platform Hub for Acellular Technologies. His independent scientific career began at the Massachusetts Institute of Technology under a NATO fellowship following a PhD and his qualification as a registered pharmacist. He returned to the UK as an EPSRC Advanced Fellow and became Professor of Tissue Engineering and Drug delivery in 2001 at the University of Nottingham. In 2013 he became a Royal Society Wolfson Merit Award Holder. He is a Sub-Panel Member for the Research Excellence Framework (REF) for 2014. In 2011 he was made a Fellow of the Royal Pharmaceutical Society and in 2013 a Fellow of the Society of Biologists. In 2014 he was selected as one of the 10 most inspirational scientists in the UK by the Engineering and Physical Sciences Research Council (RISE Leader Award). Kevin’s research involves the use of materials to control cell behavior in 3D. The applications of this research include clinical regenerative medicine and exploring stem cell differentiation. His patent inventions have led to the formation and growth of 2 UK companies.